Experimental Design:

8 week old wild-type mice were treated with PLX3397 (600 ppm in chow) for 14 days to fully deplete the brain of myeloid cells. Withdrawal of the drug then stimulates "alternative" repopulation, filling the brain with a novel myeloid cell type, which occurs in a "wave" originating from the subventricular zone of the caudate putamen. The subventricular zone was microdissected out from control, 14 days PLX3397 (microglia depleted), and 5 days of recovery (the early stages of "alternative" myeloid cell repopulation.

Use the search box to the left to display raw expression data for any gene, expressed as RPKM (Reads Per Kilobase of transcript per Million mapped reads). Individual data points, as well as means and standard errors are displayed.

This dataset accompanies the manuscript "Complete microglial elimination stimulates full reconstitution of the adult brain with distinct myeloid cells of meningeal origin, in a wave that spreads from the SVZ".